Bayer’s AI-Powered CropKey & the Arrival of Icafolin

Bayer Crop Science is redefining the future of agrochemical research with its CropKey platform, a cutting-edge AI-driven system designed to revolutionise herbicide development. Instead of relying on traditional trial-and-error methods, CropKey analyzes weed protein structures—effectively the “locks”—and virtually designs chemical molecules as “keys” that can precisely unlock and inhibit these targets. By harnessing machine learning and virtual screening, Bayer has markedly accelerated its early-stage discovery process, expanding its pipeline and producing at least three times more novel modes of action compared to just a decade ago.

The most significant breakthrough born from this technology is Icafolin, scheduled for release in Brazil in 2028. Icafolin is remarkable for being the first post-emergent herbicide with a new mode of action to reach the market in roughly 30 years. It is specifically engineered to combat highly resistant weeds such as ryegrass and waterhemp, offering targeted efficacy while minimizing collateral impact.

Bayer’s strategic vision extends far beyond a single product. Through CropKey and complementary R&D efforts, they are advancing over 30 molecular targets, with at least ten already validated in early discovery phases. Beyond herbicides, the pipeline is being diversified to include a broader-spectrum fungicide and a new insecticide—demonstrating Bayer’s commitment to a multi-modal approach to crop protection .

Equally compelling is Bayer’s commercial ambition: the company aims to launch ten blockbuster crop protection products over the next decade, each targeting a peak annual revenue of over £400 million. Icafolin alone exemplifies this ambition, with anticipated global sales well into the high hundreds of millions.

Why This Matters – and Why It Matters to You

Firstly, demonstrating knowledge of AI-driven discovery platforms like CropKey and products like Icafolin establishes your business as deeply aligned with next-generation agrochemical innovation. This level of insight is something major suppliers and brand owners look for when selecting distribution or formulation partners.

Secondly, as agricultural systems struggle with rising herbicide resistance — most notably seen in glyphosate-resistant weeds — understanding and promoting products with new modes of action is crucial. It solidifies your position as a steward-conscious partner focused on sustainable and effective weed control.

Lastly, referencing Bayer’s significant investments in R&D and their ambitious pipeline strategy communicates your comprehension of industry-wide dynamics. These include investment risks, regulatory timelines, and commercial viability—all factors that decision-makers at top-tier suppliers deeply value.